糖尿病が心臓の構造と機能に及ぼす影響: 強い心臓の研究
R B Devereux1, M J Roman, M Paranicas
1New York Hospital-Cornell Medical Center, New York, USA. rbdevere@mail.med.cornell.edu
Circulation
|May 16, 2000
まとめ
糖尿病 (DM) は独立して心臓の構造と機能を害し,左心室 (LV) 質量を増加させ,シストリック機能を低下させます. この研究は,DMDを明らかにしています.
科学分野:
- 心臓病学 心臓病学
- エンドクリノロジー エンドクリノロジー
- 公衆衛生は公衆衛生である.
背景:
- 左心室 (LV) の構造と機能に対する糖尿病 (DM) の独立した影響は,ボディマス指数 (BMI) と血圧とは別に議論され続けている.
- 心血管疾患は,糖尿病患者の主要な懸念事項です.
研究 の 目的:
- 糖尿病 (DM) が左心室 (LV) の構造と機能に及ぼす独立した影響を調査する.
- DMの患者および無患者における動脈の硬さを評価する.
主な方法:
- 強力な心臓研究でエコーカルディオグラフィーを利用し,DMの1810人の参加者と正常なグルコース耐性を持つ944人のデータを分析しました.
- 年齢,性別,BMI,血圧,治療状態を含む共変数に調整した分析を行った.
主要な成果:
- DMの参加者は,DMのない参加者と比較して,より高いLV質量と壁の厚さを示しました.
- DMの個人は,断片的縮小とストレス調整されたミッドウォール縮小を含む,LVシストリック機能の低下を示しました.
- 脈圧/脳卒中量で測定された動脈の硬さは,混同因子とは関係なく,DMの参加者において有意に高かった.
結論:
- 非インスリン依存型DMは,心臓に独立した有害な影響を及ぼし,LV質量増加,シストリック機能の障害,動脈の硬直度の上昇が特徴です.
- これらの発見は,DMの直接的な心臓効果は,BMIと血圧の上昇との関連を超えて,糖尿病患者の心血管イベントに寄与することを示唆しています.
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