プレエクラムプス症患者からのAT(1) 受容体アゴニスティック抗体は,血管細胞に組織因子の発現を引き起こします

R Dechend1, V Homuth, G Wallukat

  • 1Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charité, Humboldt University of Berlin, Germany.

Circulation
|May 24, 2000
PubMed
まとめ

アンジオテンシン-1受容体 (AT(1) -AA) を標的にする自己抗体は,血管細胞を刺激して組織因子 (TF) を発現させ,潜在的に子宮前出血症に寄与します. この研究では,ヒトの細胞に対するAT(1) -AA作用が実証され,ヒトの細胞と妊娠前出血症の病原性との関連が示されました.

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