空のスパイラクルのフェノタイプ的抑制は,ボタンヘッドによって防止されます
F Schöck1, J Reischl, E Wimmer
1Max-Planck-Institut für Biophysikalische Chemie, Abt. Molekulare Entwicklungsbiologie, Göttingen, Germany.
Nature
|June 1, 2000
まとめ
ドロソフィラの頭部発達における空のスパイラクル (ems) 遺伝子は,その活動が変化したとき,セグメントのアイデンティティを切り替えることができます. ボタンヘッド (btd) との相互作用により,EMSはHOX遺伝子階層における抑制を克服することができます.
科学分野:
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
背景:
- ドロソフィラの前頭部セグメントは,ペアルールおよびHOX-クラスター遺伝子とは独立して発達する.
- ortodenticle (otd), empty spiracles (ems), buttonhead (btd) を含むギャップのような遺伝子は,頭部セグメント形成を調節する.
- Empty spiracles (ems) はHOXのようなホメオドメインを有し,HOX-クラスター遺伝子の活性が欠けていてもトランクセグメントの同一性を授与することができます.
研究 の 目的:
- ドロソフィラセグメントの同一性における空のスパイラクル (ems) とボタンヘッド (btd) の役割を調査する.
- HOX遺伝子階層の文脈で,emsとbtdの相互作用を解明する.
主な方法:
- ドロソフィラ胚におけるEMSとBTDの誤表現実験.
- EMSとBTDタンパク質の相互作用に関する試験.
主要な成果:
- ヘッドにおけるEMSの誤った表現は,btdに依存した方法でセグメントのアイデンティティを変化させます.
- トランクにおけるBTDの誤発現は,エムス依存構造を誘発する.
- EMSとBTDのタンパク質は,in vitroで相互作用する.
結論:
- EMSとBTDの相互作用により,EMSはHOX遺伝子階層内の抑制から逃れることができます.
- この相互作用は,前後軸に沿ったホメオティック流行の支配的なスイッチを容易にする可能性があります.
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