麻酔した豚の血レニン活性に対する胆囊の膨張の効果
C Molinari1, E Grossini, D A Mary
1Dipartimento di Scienze Mediche, Facoltà di Medicina e Chirurgia di Novara, Università del Piemonte Orientale A. Avogadro, and the Servizio di Chirugia Sperimentale, Azienda Sanitaria Ospedaliera "Maggiore della, Novara, Italy.
Circulation
|June 1, 2000
まとめ
胆囊の膨張は,陰道および交感経路経由でプラズマレニン活性 (PRA) を反射的に増加させます. このレニンの放出は,血管収縮を含む心血管の変化に寄与する.
科学分野:
- 心血管生理学 心血管の生理学
- 腎臓生理学 腎臓生理学
- 自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous Nervous System) とは,自律神経系 (Autonomous
背景:
- 胆管病理は,心血管疾患と関連しています.
- 豚の胆囊の膨張は,同情的メカニズムを通じて心拍数と血圧を上昇させます.
- 交感出力はレニン放出とアンジオテンシン生成に影響する.
研究 の 目的:
- 胆管の膨張がプラズマレニン活性 (PRA) を反射的に変化させるかどうかを判断する.
- 胆囊の膨張によって引き起こされるPRAの変化がプレッサー,冠動脈,および地域血管抵抗応答に及ぼす影響を評価する.
主な方法:
- 麻酔した豚で気球を用いた胆管の膨張.
- PRA,血圧,心拍数,および地域血管抵抗の測定.
- ヴァゴトミー,腎不全,ベータアドレナージック阻害,アンジオテンシンII受容体阻害による介入.
主要な成果:
- 胆囊の膨張は,尿中のナトリウム分泌に影響を与えることなく,PRAを増加させた.
- PRAの上昇は,ヴァゴトミー,腎臓の消去,またはベータアドレネルジックブロックによって廃止されました.
- アンジオテンシンII受容体阻害は圧縮器と血管収縮の反応を弱めた.
結論:
- 無害な胆囊の膨張は,反射的にPRAを上昇させる.
- このレニン放出は,ヴァーガルアフェレンタルとシンパティックエフェレンタル経路 (β-アドレナージ) を含む.
- 高濃度のPRAは,胆囊の膨張時に圧力器と血管収縮反応に大きく寄与する.
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