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大人の神経幹細胞の汎用的な可能性

D L Clarke1, C B Johansson, J Wilbertz

  • 1Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden.

Science (New York, N.Y.)
|June 2, 2000
PubMed
まとめ

成人の神経幹細胞は,幅広い発達能力を持ち,キメリック胚のすべての生殖層に貢献します. この発見は,再生医療と疾患治療における神経幹細胞の潜在的応用を拡大する.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...