ヴァガス神経の刺激は,エンドトキシンに対する全身の炎症反応を弱める
L V Borovikova1, S Ivanova, M Zhang
1The Picower Institute for Medical Research, Manhasset, New York 11030, USA. lborovikova@mindspring.com
Nature
|June 6, 2000
まとめ
脳は,迷走神経を介して炎症を調節する. この研究は,アセチルコリン放出が炎症性サイトカインを阻害し,致死性エンドトキセミアショックを防ぐパラシンパシー経路を明らかにしています.
科学分野:
- 神経科学は神経科学である.
- 免疫学 免疫学とは
- 生理学 生理学とは
背景:
- ホメオスタシスは,プロおよび抗炎症反応のバランスを取ることに依存しています.
- グラム陰性細菌からのエンドトキシンが致死性サイトカインの放出を誘発します.
- 中枢神経系は全身の炎症を調節するが,その間にある迷走神経の役割は不明である.
研究 の 目的:
- 系統的炎症反応を調節するエフェレントの迷走神経の信号伝達の役割を調査する.
- 以前未知のパラシンパティック抗炎症経路を特定するために.
主な方法:
- リポポリサッカリド刺激によるヒトマクロファージにおけるサイトカインの放出に対するアセチルコリンの効果を調べた.
- 致死性エンドトキセミアのラットにおける外周の迷走神経を刺激した.
主要な成果:
- アセチルコリン減弱型プロ炎症性サイトカインの放出 (TNF,IL-1β,IL-6,IL-18) はありますが,IL-10は含まれていません.
- ヴァガス神経刺激は,TNF合成を阻害し,エンドトキセミックラットのショックを予防しました.
結論:
- 炎症を制御する際に,迷走神経とアセチルコリンを巻き込む新しいパラシンパシー経路を特定した.
- この経路は,エンドトキセミアのような炎症性疾患の潜在的治療標的を提供します.
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