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Updated: May 6, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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CTCF依存の境界のメチル化は,Igf2遺伝子のインプリント表現を制御する

A C Bell1, G Felsenfeld

  • 1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0540, USA.

Nature
|June 6, 2000
PubMed
まとめ

ゲノムインプリントは遺伝子発現を調節する. CTCF依存の絶縁剤は,強化剤の活性を阻害することによって,インプリント遺伝子発現を制御し,DNAメチル化により,その機能を特定のアレルに制限する.

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