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関連する概念動画

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
Global Regulatory Systems01:28

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

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関連する実験動画

Updated: May 9, 2026

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
06:21

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

自己調節による遺伝子ネットワークにおけるエンジニアリングの安定性.

A Becskei1, L Serrano

  • 1EMBL, Structures & Biocomputing, Heidelberg, Germany. becskei@embl-heidelberg.de

Nature
|June 13, 2000
PubMed
まとめ

遺伝子回路の負のフィードバックループは,細胞システムの安定性を高めます. この研究は,これらの調節メカニズムが,細胞機能に不可欠な生化学的パラメータの変動を制限する方法を示しています.

科学分野:

  • システム生物学 システム生物学
  • 分子生物学は分子生物学である.
  • 遺伝学 遺伝学とは

背景:

  • 細胞のホメオスタシスと発達は,遺伝的および生化学的なネットワークに依存しています.
  • これらのネットワークは,転写,翻訳,分解率の変動を許容しなければならない.
  • 細胞の多様性は,環境刺激とストキャスティックな生化学プロセスから生じる.

研究 の 目的:

  • 遺伝子回路における自己調節性負のフィードバックループの安定作用を調査する.
  • ネットワークコンポーネントの変動を制限する際にネガティブなフィードバックの有効性を実証する.

主な方法:

  • エシェリキア・コライの単純な遺伝子回路の設計と構築.
  • 調節器と転写抑制器モジュールの組み込み.
  • 回路の安定性の実験的検証.

主要な成果:

  • エンジニアリングされた遺伝子回路における安定性の獲得が実証されています.
  • ネガティブなフィードバックループは,成分濃度の変動の範囲を制限することが示されました.
  • この研究は,フィードバックの安定効果が提案されていることを実証する実験的証拠を提供します.

さらに関連する動画

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
08:20

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

Published on: September 2, 2021

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

関連する実験動画

Last Updated: May 9, 2026

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness
06:21

An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness

Published on: May 7, 2018

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization
08:20

A New Toolkit for Evaluating Gene Functions using Conditional Cas9 Stabilization

Published on: September 2, 2021

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
09:20

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells

Published on: July 6, 2021

結論:

  • ネガティブなフィードバックは,生物学的ネットワークの安定性を達成するための重要なメカニズムです.
  • ネガティブなフィードバックを持つ遺伝子回路は,細胞の強さを理解するためのモデルを提供します.
  • この研究は,ネガティブなフィードバックループが遺伝子規制ネットワークに安定性を与えるという仮説を支持する.