幅広いスペクトルの日焼け止めの使用と白人の子供における新しいネボの発生:ランダム化制御試験
R P Gallagher1, J K Rivers, T K Lee
1Cancer Control Research Program, British Columbia Cancer Agency, 600 W Tenth Ave, Vancouver, British Columbia, Canada V5Z 4E6. rickg@bccancer.bc.ca
JAMA
|June 24, 2000
まとめ
ブロードスペクトルの日焼け止めを使用すると,白人の子供における新しいモールの発症が著しく減少しました. この効果は,特に雀斑の子どもでは顕著であり,メラノーマの危険因子を予防する上で日焼け止めが重要な役割を果たすことを示唆しています.
科学分野:
- 小児皮膚科の皮膚科について
- 予防医学は,予防的な医療です.
- 腫瘍学 腫瘍学
背景:
- メラノサイト性ネヴィの高密度は,皮膚性悪性メラノーマの既知の危険因子です.
- ネウスの発達,特に子供では,日光曝露と強く関連しています.
- 早期介入戦略は,メラノーマのリスクを軽減するために極めて重要です.
研究 の 目的:
- ブロードスペクトル,高太陽保護因子 (SPF) の日焼け止めがネブスの発症を予防する効果を調査する.
- 日焼け止めの使用が白人の子供における新しいネヴィウの形成を弱めることができるかどうかを判断する.
- メラノーマの主要な危険因子に対する日焼け止めの影響を評価する.
主な方法:
- ブリティッシュ・コロンビア州バンクーバーの309人の白人学童 (1年生から4年生) を対象としたランダム化制御試験です.
- 介入グループ (n=222) はSPF30の広範囲の日焼け止めを投与され,対照グループ (n=236) は日焼け止めやアドバイスを受けなかった.
- ネヴィウスの数は,ベースラインと3年後に数えられ,新しいネヴィウスの獲得はグループ間で比較されました.
主要な成果:
- 日焼け止めを使用した子どもは,対照群と比較して,新規ネヴィウが著しく少なくなった (中位数24対28,P=.048).
- フレークリングと研究グループとの間に有意な相互作用が観察され,フレークリングの子供にとってより大きな利益が強調されました.
- モデリングは,日焼け止めを使用している斑点のある子どもは,新しい神経の発達に30%から40%の減少を経験することが示唆されています.
結論:
- 幅広いスペクトルの日焼け止めは,白人の子供における神経の発達を弱める可能性を示しています.
- 日焼け止めの保護効果は,ニンニクのある子供にとって特に重要です.
- 一貫した日焼け止めの使用は,子供の頃のメラノーマの危険因子を減らすための効果的な戦略かもしれません.
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