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Genomics02:02

Genomics

35.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.5K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

11.8K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
16.7K
Ribosome Profiling02:24

Ribosome Profiling

3.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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The Central Dogma01:20

The Central Dogma

21.2K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Proteomics01:33

Proteomics

7.5K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

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ポストゲノム時代のタンパク質の機能

D Eisenberg1, E M Marcotte, I Xenarios

  • 1Molecular Biology Institute and UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California at Los Angeles, 90095-1570, USA. david@mbi.ucla.edu

Nature
|June 24, 2000
PubMed
まとめ
この要約は機械生成です。

機能的ゲノミクスは,膨大なゲノムデータを生物学的知識に変換することを目的としています. このフィールドでは,配列およびメッセンジャーRNA発現データを意味のある洞察に合成する方法について説明します.

さらに関連する動画

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

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関連する実験動画

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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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科学分野:

  • ゲノミクスゲノミクスとは
  • 分子生物学は分子生物学である.
  • バイオインフォマティックス

背景:

  • 生物学的研究は,大量にゲノムおよびメッセンジャーRNA (mRNA) 発現データを生成しています.
  • 課題は,この大量のデータを,実行可能な科学的知識に変換することです.
  • 現在のデータ処理方法は,多様な生物学的情報を効果的に合成するのに苦労しています.

研究 の 目的:

  • 機能的ゲノミクスの新興分野を探求する.
  • 広範なゲノムおよび発現データから意味のある知識を導き出す方法についての重要な問題に取り組むために.
  • 機能的ゲノミクスによって生み出される知識の潜在的形態と応用を定義する.

主な方法:

  • ゲノムデータの生成における現在の動向の分析.
  • 高通量表現プロファイリング技術 (例えば,マイクロアレイ) のレビュー.
  • 生物学における知識合成のための概念的枠組みの開発.

主要な成果:

  • 生物学におけるデータ生成と知識獲得の間の大きなギャップを特定しました.
  • 複雑な生物学的データセットを統合・解釈するための新しいアプローチの必要性を強調した.
  • この課題に取り組むための重要な分野として機能的ゲノミクスを確立しました.

結論:

  • 機能的ゲノミクスは,大規模な生物学的データを生物学的理解に変換するための経路を提供します.
  • ゲノムと発現データの効果的な合成は,生物学的発見を前進させるために不可欠です.
  • この分野は,生物学的知識の生成と利用の方法を再構築することを約束しています.