新しいミレニアムにおける遺伝的決定因子の探求
1Department of Genetics, Stanford University School of Medicine, California 94305-5120, USA.
Nature
|June 24, 2000
まとめ
人間の遺伝学は,一般的な病気の遺伝子を特定する上で課題に直面しています. 大規模な全ゲノム研究を用いたポストゲノム戦略は,複雑な遺伝疾患を理解するための新しい機会を提供します.
科学分野:
- ヒューマン・ジェネティクス ヒューマン・ジェネティックス
- ゲノム医学はゲノム医学である.
- 複合疾患の遺伝学 複合疾患の遺伝学
背景:
- 現在の分子方法は,希少なメンデルの症候群の遺伝子を識別するのに優れています.
- これらの方法は,一般的な,家族的,非メンデルの疾患の基礎となる遺伝子を発見するのに不十分です.
- 人間のゲノム配列の完成は,遺伝子研究のための新しい道を開く.
研究 の 目的:
- ヒト遺伝学研究における課題をレビューする.
- 複雑な遺伝疾患に関するポストゲノム研究の戦略について議論する.
- ポストゲノム時代における最適なアプローチの提案をすること.
主な方法:
- ヒト遺伝学の現在の文献と方法論のレビュー.
- 大規模な全ゲノム研究に関する議論.
- 複雑な遺伝的特徴の研究のための戦略の分析.
主要な成果:
- 伝統的な方法は,複雑な非メンデルの疾患では不十分です.
- ゲノム全体の研究は,将来の遺伝学的発見にとって極めて重要です.
- 最も効果的なポストゲノム研究戦略について議論があります.
結論:
- 一般的な疾患の遺伝的基礎を解明するために,新しいアプローチが必要である.
- 大規模な全ゲノム研究は,ヒト遺伝学の進歩に不可欠です.
- ゲノムデータを最適に活用するには,戦略的計画が必要です.
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