低密度リポプロテインの分泌後の改変,単細胞機能,およびマクロ血管系の合併症があるか否かの2型糖尿病患者の循環中の粘着分子:アルファ-トコフェロールサプリメントの効果
1Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9073, USA.
Circulation
|July 13, 2000
まとめ
この研究は,マクロ血管疾患に関係なく,2型糖尿病は単細胞の活動と粘着を増加させることを示しています. RRR-α-トコフェロール療法は,糖尿病患者におけるこれらのプロアテロゲン効果を効果的に軽減しました.
科学分野:
- 心血管研究 循環器科の研究
- エンドクリノロジー エンドクリノロジー
- 免疫学 免疫学とは
背景:
- 糖尿病は動脈硬化を加速する.
- マクロ血管疾患の有無で,2型糖尿病における単細胞活動とLDLの変異は十分に理解されていません.
- これらの要因に対するRRR-α-トコフェロール (AT) の影響を調査することは極めて重要です.
研究 の 目的:
- (DM2-MV) と (DM2) のマクロ血管疾患のない2型糖尿病患者のLDLの改変,単細胞のプロアテロゲン活性,および溶性細胞粘着分子 (sCAM) を対照群と比較するために.
- 3つのグループにおけるこれらのパラメータに対するRRR-α-トコフェロール (AT) 療法の効果を評価する.
主な方法:
- LDLの糖化と酸化を比較した分析.
- モノサイトスーパーオキシドアニオン (O(2)(-)) とインタールイキン-1β (IL-1β) の放出の評価.
- 単細胞の内皮への粘着と循環中のsCAMのレベルを測定する.
- RRR-アルファ-トコフェロール (AT) を1200 IU/日で3ヶ月間投与した介入.
主要な成果:
- 糖尿病のグループでは,AT治療の影響を受けず,LDLグリケーションが増加しました.
- AT療法はすべてのグループでLDLの酸化性を低下させた.
- 糖尿病の単細胞は,対照群と比較して,O(2)(-),IL-1βの放出,および内皮粘着が増加した.
- AT療法は,すべてのグループでモノサイトO (((2) (((-),IL-1β,腫瘍死滅因子α,および粘着を著しく減少させた.
- DM2群とDM2-MV群の間では,単細胞活動やLDLパラメータの有意な差異は見つかりませんでした.
- sCAMレベルは糖尿病グループでは上昇し,AT療法によって低下しました.
結論:
- 2型糖尿病は,マクロ血管系の合併症に関係なく,モノサイトのプロアテロゲン活性と粘着性を高めます.
- RRR-α-トコフェロール (AT) 療法は,これらの糖尿病に関連したプロアテロゲン変化を効果的に軽減します.
- この研究は,糖尿病における単細胞の行動とATの治療的可能性に関する新しい洞察を提供します.
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