エイズに感染した子供のがんのリスク. エイズとがんのマッチングレジストリ研究グループ
R J Biggar1, M Frisch, J J Goedert
1VEB/NCI, 6120 Executive Blvd, Room 8014, Bethesda, MD 20852. Biggarb@epndce.nci.nih.gov
JAMA
|July 13, 2000
まとめ
既得免疫不全症候群 (AIDS) を患っている子どもは,特定のがん,特にノンホッジキンリンパ腫と原発性脳リンパ腫のリスクが著しく増加します. また,レオミオサルコマは,エイズに関連した小児がんの1つとして注目されています.
科学分野:
- 小児腫瘍学 小児腫瘍学
- 感染症 感染症は感染症です.
- エピデミオロジー エピデミオロジー
背景:
- 獲得免疫不全症候群 (AIDS) の子供のがんに関する人口ベースのデータは限られている.
- これらのがんのスペクトルとリスクを理解することは,小児のケアにとって極めて重要です.
研究 の 目的:
- 獲得免疫不全症候群 (AIDS) と関連した小児がんのリスクを決定する.
主な方法:
- エイズと診断された子供 (≤14歳) の11の米国地域 (1978年-1996年) のデータをがん登録簿にリンクした.
- エイズ発症後の2年間の癌の頻度,発生率,相対リスク (RR) を分析した.
主要な成果:
- エイズ患者の4954人の子供のうち,124人が癌,100人がノンホッジキンリンパ腫 (NHL),8人がカポシ肉腫 (KS) でした.
- NHLの発生率は高かった (RR, 651),特に一次性脳リンパ腫 (RR, 7143).
- レオミオサルコマとホジキン病のリスクも高かった; KSはエイズ診断の近くで発生し,他のものは後に現れた.
結論:
- 小児のエイズ関連がんは,レオミオサルコマが追加され,成人のパターンを反映しています.
- 主要な脳リンパ腫とレオミオサルコマは,子どもたちのエイズ発症から数年後にしばしば発生しました.
- 希少がんの相対リスクの推定値は,数値が小さいことと不正確さのために慎重に解釈する必要があります.
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