関連する実験動画

Updated: Jul 17, 2026

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
12:24

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

Published on: July 2, 2010

RNA結合タンパク質Pub1は,上流のオープン読書フレームを含むトランスクリプトの安定性を調節する

M J Ruiz-Echevarría1, S W Peltz

  • 1Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA. ruizeche@umdnj.edu

Cell
|July 13, 2000
PubMed
まとめ

Nonsense-mediated decay (NMD) は,上流のオープン・リーディング・フレーム (uORF) を用いたトランスクリプトをターゲットにしている. しかし,Pub1タンパク質と相互作用するいくつかのmRNAの安定化要素 (STE) は,NMDを防止し,遺伝子発現を調節します.

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mRNA Interactome Capture from Plant Protoplasts

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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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