関連する実験動画
Updated: Jul 18, 2026

23:06
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
流行病地域における薬剤耐性結核の分類
A Van Rie1, R Warren, M Richardson
1Department of Paediatrics and Child Health, University of Stellenbosch, South Africa.
Lancet (London, England)
|July 13, 2000
まとめ
薬剤耐性結核の伝統的な分類は誤解を招いている. 制限断片長ポリモルフィズム (RFLP) は,薬剤耐性菌株の伝播を半分以上の症例で明らかにし,用語修正の必要性を強調しました.
科学分野:
- 分子疫学分子疫学について
- 感染症の伝播は,感染症の伝播である.
- 公衆衛生の監視は,公衆衛生の監視である.
背景:
- 薬剤耐性結核の伝統的な分類は,治療歴に依存しています.
- 主要薬剤耐性は,歴史的に,薬剤耐性菌株の伝播にのみ起因しています.
研究 の 目的:
- 薬剤耐性結核における薬剤耐性菌株の伝播の寄与を評価する.
- 分子型化の結果を伝統的な臨床分類と比較する.
主な方法:
- 南アフリカのケープタウンで63人の薬剤耐性結核患者の記述的研究.
- ストレントイピングのために制限断片長ポリモルフィズム (RFLP) を利用した.
- RFLPの発見を従来の患者分類と比較した.
主要な成果:
- 制限断片長ポリモルフィズム (RFLP) は,薬剤耐性結核症例の52%で感染が原因であると特定しました.
- 多剤耐性結核の感染割合は,単剤耐性結核の感染率よりも高かった (64%).
- 伝統的な分類では,25人の患者に誤って感染が確認された.
結論:
- "獲得薬物耐性"という用語は,誤って真の獲得と伝播の両方を含んでいる.
- 誤った分類は,欠陥のある監視,プログラム評価,治療の遅延につながる可能性があります.
- "既得薬物耐性"を"以前に治療された症例における薬物耐性"に置き換えることを推奨する.
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