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ホリオカルシノマと部分的水性形モール
M J Seckl1, R A Fisher, G Salerno
1Department of Medical Oncology, Imperial College, London, UK. m.seckl@ic.ac.uk
Lancet (London, England)
|July 13, 2000
まとめ
部分性水分型モール (PMs) は,希少だが攻撃的な妊娠期トロフォブラスティック疾患の形態であるホリオカルシノーマに変容することがあります. この研究は,変容を確認し,PMの疑わしい症例のヒト胆管性ゴナドトロピン (hCG) フォローアップの必要性を強調しています.
科学分野:
- 生殖医学は,生殖器医学である.
- 婦人科腫瘍学 婦人科腫瘍学
- 遺伝学 遺伝学とは
背景:
- 部分性水滴形モール (PMs) は,化学療法とめったに関連せず,その変異が胆がんに転化することは以前は確立されていませんでした.
- PMが胆 ?? 癌に進行する可能性は,ヒト胆 ?? 球原蛋白 (hCG) のモニタリングの必要性について疑問を投げかけます.
研究 の 目的:
- 部分水分型モール (PMs) がホリオカルシノーマに変容する可能性を調査する.
- PMsと,その後のホリオカルシノーマ発症との関係を確立するためです.
主な方法:
- 妊娠期トロフォブラスティック疾患 (GTD) データベースからコリオカルシノーマを発症したPM患者さんを特定しました.
- ヒストロジーをレビューし,フローサイトメトリーでトリプロイド状態を検証し,マイクロサテライトポリモルフィズムを使用してDNAを比較し,PMからホリオカルシノーマの起源を確認しました.
主要な成果:
- 3000人のPM患者のうち3人が,化学療法を必要とする胆がんを発症した.
- 遺伝分析により,PMから発生したホリオカルシノマが確認され,同一の母性および2つの父性アレルが示されました.
- 3つのケースでPMトリプロイドが確認されました.
結論:
- 部分性水分型モール (PMs) は,胆がんに変容することがあります.
- 疑わしいPMの中央審査は極めて重要です.
- 確認されたPM症例は,悪性変異を検出するためにヒト胆管性ゴナドトロピン (hCG) のフォローアップを必要とします.
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