シグナルトランスデュークション. FasLは,事前に組み立てられた Fas Fasを結合します

P Golstein¹

¹Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, 13288 Marseille Cedex 9, France. golstein@ciml.univ-mrs.fr

Science (New York, N.Y.)

|August 5, 2000

まとめ

Fas受容体は,リガンド結合の前にトリマーに組み立てられ,信号伝導の伝統的な見解に異議を唱える. このプレアセンブリは,その後の死亡信号の送信のために受信機を準備します.

科学分野:

細胞生物学細胞生物学
分子シグナル伝達です.
免疫学免疫学とは

背景:

伝統的に,リガンド結合は受容体媒介信号伝導の主要なトリガーと考えられています.
Fas受容体は,アポプトーシス (プログラム細胞死) を開始する上で重要な役割を果たします.

研究の目的:

Fas受容体のプリリガンド結合アセンブリ状態を調査する.
Fas受容体のプレアセンブリがリガンド結合およびその後の信号伝導に影響を与えるかどうかを判断する.

主な方法:

この研究は,Chan et al.の調査結果を引用しています. そして,Siegel et al. Fas受容体の行動について.
抽象は,受容体組成を観察するために実験的または計算的方法が使用されたことを示しています.

主要な成果:

Fas受容体は,その特定のリガンドがない場合,トリマーにプリアセンブルすることが観察されています.
このリガンド独立トリメリゼーションは,効果的なリガンド結合の前提条件であるようです.

結論:

ファス受容体のプレアセンブリは,ファス媒介信号伝導の開始において,これまで認識されなかった重要なステップである.
この発見は,Fas経路経由で死亡シグナルがどのように開始されるかについてのモデルの見直しを必要としています.

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