ヒト腫瘍内皮に発現する遺伝子
B St Croix1, C Rago, V Velculescu
1Johns Hopkins Oncology Center, Howard Hughes Medical Institute, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Science (New York, N.Y.)
|August 19, 2000
まとめ
研究者らは,正常な血管細胞と腫瘍血管細胞の遺伝子発現を比較した. 彼らは,正常細胞とは異なる腫瘍内皮の特定の分子マーカーを特定し,抗血管新生療法に情報を提供することができました.
科学分野:
- 分子生物学は分子生物学である.
- 腫瘍学 腫瘍学
- 血管生物学 血管生物学
背景:
- 腫瘍血管新生は,がんの成長と転移に不可欠です.
- 正常血管系と腫瘍血管系の分子の違いを理解することは,標的治療の鍵です.
研究 の 目的:
- 正常および悪性結腸組織間の内皮細胞の分子差異を特定する.
- 潜在的な治療目標のための新しい腫瘍内皮マーカーの発見.
主な方法:
- 正常および腫瘍の結腸直腸組織から分離された内皮細胞の遺伝子発現プロファイリング.
- 微分表現分析により,著しく変化したトランスクリプトを特定する.
主要な成果:
- 170以上の内皮が優勢であるトランスクリプトを分析した.
- 79のトランスクリプトは異なる発現を示し,46のトランスクリプトは特に腫瘍内皮で上昇した.
- 特定された腫瘍内皮マーカーは,傷の治癒と体形成の間に正常な血管にも発見されました.
結論:
- 腫瘍と正常な内皮は,異なる分子プロファイルを示します.
- 新しい腫瘍内皮マーカーは,抗血管新生療法の標的として機能する可能性があります.
- これらの発見は,血管新生依存性疾患の標的治療の開発の可能性を強調しています.
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