食事パターンが血清ホモシステインに与える影響:ランダム化,制御された給餌試験の結果
L J Appel1, E R Miller, S H Jee
1Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA. lappel@welch.jhu.edu
Circulation
|August 23, 2000
まとめ
食事のパターンは,心血管疾患の危険因子であるホモシステインのレベルに大きく影響します. 果物,野菜,低脂肪乳製品に富んだ食生活は,対照または果物/野菜のみの食生活とは異なり,ホモシステインを低下させた.
科学分野:
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- 心血管の健康についてです.
- メタボリック研究
背景:
- ホモシステイン濃度の上昇は,動脈硬化性心血管疾患のリスクの増加と関連しています.
- ホモシステインに対するビタミンサプリメントの効果に関する研究は広範囲にわたるが,食事パターンへの影響は依然として理解されていない.
研究 の 目的:
- 断食中の全血清ホモシステイン濃度に対する食生活の変化の影響を調査する.
- 心血管疾患リスクの文脈で食事とホモシステインの関係を探求する.
主な方法:
- 3週間の試行期間をコントロールダイエットで,その後8週間の介入期間を3つのランダムに割り当てられたダイエットで実施しました.
- ダイエットには,コントロール,果物と野菜が豊富で,果物,野菜,低脂肪乳製品,減脂食品の組み合わせが含まれていました.
- ホモシステインのレベルは,多変量回帰分析で,介入前と後に測定されました.
主要な成果:
- 併用食はホモシステインレベルを有意に低下させた (-0.34マイクロモール/L,P=0.03対照群).
- 果物と野菜の食事は,非有意な減少を示した (+0.21マイクロモール/L,P=0.47対照群).
- ホモシステインの変化は血清葉酸 (P=0.03) と逆に関連していたが,ビタミンB12やB6.0は関連していなかった.
結論:
- ダイエットパターンの変更は,断食中の全血清ホモシステインに実質的に影響を与える可能性があります.
- これらの発見は,食生活が動脈硬化性心血管疾患の発達にどのように影響するかについての洞察を提供します.
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