羊の心筋の代謝の周産変化
B Bartelds1, H Knoester, G B Smid
1Division of Pediatric Cardiology, Department of Pediatrics, Beatrix Children's Hospital, Groningen, The Netherlands. b.bartelds@planet.nl
Circulation
|August 23, 2000
まとめ
心筋の酸素消費量は,胎児の羊のグルコースから新生児の長鎖脂肪酸 (LC-FA) に変化する. 胎児の羊は,LC-FAを供給されたときにエネルギーとして利用することができ,心筋基板利用の適応性を示しています.
科学分野:
- 心臓病学 心臓病学
- 新生児生理学 新生児生理学
- メタボリック研究
背景:
- 乳酸は,新生児における重要な心筋酸素消費体である.
- 大人の心臓代謝の主な燃料源である長鎖脂肪酸 (LC-FA) は,胎児と新生児の心臓において疑問視されている.
- 新生児の心臓健康にとって,心筋基板利用の理解は極めて重要です.
研究 の 目的:
- 胎児および新生児の羊の心筋におけるグルコースとLC-FAの代謝運命を調査する.
- 胎内期間中の心筋の酸素消費に対するグルコースとLC-FAの貢献度を測定する.
- LC-FAをエネルギー基質として利用する胎児の心臓の能力を評価する.
主な方法:
- 安定同位体トレーサーである[U-(13) C]グルコースと[1-(13) C]パルミタートは,慢性的に計測された胎児および新生児の子羊に用いられました.
- 測定された心筋膜基質の酸化率と,その合計酸素消費への貢献.
- LC-FA供給を増やし,代謝反応を評価するために,胎児の羊に脂肪エムルションを投与しました.
主要な成果:
- 胎児の子羊では,グルコースが主要基質 (48%) であり,LC-FA酸化は最小限 (2%) であった.
- 新生児の子羊では,LC-FA酸化が有意に増加し (83%),グルコース酸化が減少した (12%).
- 脂肪注入の間,胎児の羊のLC-FAの酸化は15倍に増加し,心筋の酸素消費に大きく (70%) 貢献しました.
結論:
- 心筋基板の利用は,胎児のグルコースから,新生児のLC-FAへと劇的に変化する.
- 胎児の心筋は,LC-FAを,利用可能な限り,実質的なエネルギー源として利用する能力を有しています.
- これらの発見は,新生児の心臓のエネルギー代謝における重要な発達変化を明らかにします.
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