NMDAR1の皮質限定破壊は,小樽皮質のニューロンパターンを損なう
T Iwasato1, A Datwani, A M Wolf
1Laboratory for Behavioral Genetics, Brain Science Institute, RIKEN, Saitama, Japan.
Nature
|August 30, 2000
まとめ
皮質のN-メチル-D-アスパルテート受容体 (NMDARs) は,感覚マップの発達に不可欠です. 興奮性ニューロンにおけるNMDAR1の削除は,体感覚皮質の樽形成とタラモコルチカルパターニングを妨げます.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学とは
- センサリーシステム センサリーシステム
背景:
- 体感覚皮質には,ひげや足のような感覚の入力に関するトポグラフィックな表現が含まれています.
- 神経活動,特にN-メチル-D-アスパルテート受容体 (NMDARs) 経由は,感覚マップの発達に関与していますが,その正確な役割については議論されています.
研究 の 目的:
- ソマトセンサリー皮質の地図と構造の開発のために皮質NMDARの必要性を調査する.
主な方法:
- 遺伝子組み換えマウスを生成し,NMDAR1遺伝子を消去し,特に刺激性皮質ニューロンに特化した.
- これらのマウスを用いて,脳幹,タラマス,体感覚皮質の感覚経路の発達を調べました.
主要な成果:
- 脳幹とタラムスの感覚マップは正常に発達した.
- 皮質では,大きなひげのためのthalamocortical afferentsは,いくつかのパターンと可塑性を示したが,コントロールよりもはっきりしない.
- シヌス毛や指のパターンはほとんど見られませんでした.
- 細胞集積 (バレル) とその境界は,アフェレンツが集結した場所でも形成されませんでした.
結論:
- 皮質のNMDARは,層IVの細胞をバレルに適切に集積するために不可欠です.
- NMDARは,体感覚皮質のタラモコルチカルパターンの完全な発達のために必要である.
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