関連する実験動画

Updated: May 6, 2026

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation
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Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation

Published on: November 26, 2011

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PAK1の構造は,自己抑制された形状で,多段階の活性化スイッチを明らかにします

M Lei1, W Lu, W Meng

  • 1Laboratory of Molecular Medicine, Children's Hospital, Boston, Massachusetts 02115, USA.

Cell
|September 7, 2000
PubMed
まとめ

p21活性化キナーゼ (PAKs) は,GTPase結合によって調節され,そのダイマー構造が破壊されます. この形状の変化はキナーゼ領域を活性化し,細胞構造と機能に関与する下流信号伝達経路を可能にします.

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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

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