喫煙者の冠動脈疾患:ビタミンCは冠動脈の微循環機能を回復する
P A Kaufmann1, T Gnecchi-Ruscone, M di Terlizzi
1MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Circulation
|September 12, 2000
まとめ
喫煙は,大動脈の冠動脈血流と,酸化ストレスによる微循環の両方を損なう. 抗酸化物質のビタミンCは,喫煙者の冠動脈の流れを回復させ,その潜在的治療的役割を強調した.
科学分野:
- 心血管医学 心血管医学
- 酸化ストレス研究 酸化ストレス研究
- 薬理学 薬理学とは
背景:
- 冠動脈疾患のない喫煙者は,冠動脈内皮機能と血管運動の障害を示します.
- 喫煙者におけるこれらの血管障害の疑わしい原因は,酸化ストレスの増加である.
研究 の 目的:
- 喫煙が冠動脈の微循環と心筋の血流調節に及ぼす影響を調査する.
- ビタミンCが喫煙者の冠動脈の流れを回復できるかどうかを判断する.
主な方法:
- ポジトロン放出トモグラフィーは,喫煙者11人と対照者8人の冠動脈流量準備量を測定するために使用されました.
- 抗酸化物質であるビタミンCを投与する前と後に測定を行った.
主要な成果:
- ベースラインの冠動脈フロー・リザーブは,喫煙者において対照群と比較して21%低かった (P<0.05).
- ビタミンCは喫煙者の冠動脈の流れを正常化したが,対照群には効果がなかった.
- これは,喫煙による酸化促進効果が冠動脈の微循環にまで及ぶことを示唆している.
結論:
- 喫煙による酸化ストレスが冠動脈の微循環と心筋の血流調節を損なう.
- ビタミンCの投与は,喫煙者における冠動脈の微循環反応と冠動脈の流れの減少を回復します.
- これらの発見は,酸化ストレスが喫煙による血管損傷に大きく寄与する証拠を提供します.
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