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Updated: Jun 17, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Smoothened and Patchedの腫瘍性変異の効果は,サイクロパミンによって逆転させることができます

J Taipale1, J K Chen, M K Cooper

  • 1Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Nature
|September 13, 2000
PubMed
まとめ

植物由来化合物であるサイクロパミンは,ヘッジホッグ (Hh) 信号伝達経路を阻害する. この化合物は,スムージド (SMO) またはパッチド (PTCH) 変異によって引き起こされる様々なヒト腫瘍に対する治療薬としての潜在能力を示しています.

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis07:26

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