Search research articles

お問い合わせ

JoVEについて

概要リーダーシップブログ JoVEヘルプセンター

著者向け

出版プロセス編集委員会範囲と方針査読よくある質問投稿

図書館員向け

推薦の声購読アクセスリソース図書館諮問委員会よくある質問

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments アーカイブ

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教員リソースセンター教員サイト

プライバシーポリシー

関連する概念動画

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え

Same author

Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a.

Oncogene·2016

Same author

[Not Available].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2015

Same author

The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins.

Molecular psychiatry·2014

Same author

Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.

Oncogene·2012

Same author

Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity.

British journal of pharmacology·2011

Same author

Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner.

Oncogene·2008

Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026

Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026

Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026

Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026

Same journal

Dementia risk in middle-aged people linked to a blood protein.

Nature·2026

Same journal

Daily briefing: What's really happening with trust in science.

Nature·2026

関連記事をすべて見る

Search research articles

関連する実験動画

Updated: Jun 25, 2026

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

APC腫瘍抑制器は,核輸出機能を備えています.

R Rosin-Arbesfeld¹, F Townsley, M Bienz

¹Laboratory of Molecular Biology, Cambridge, UK.

|September 13, 2000

まとめ

この要約は機械生成です。

アデノマ型ポリポシス・コーライ (APC) タンパク質の変異は,その核輸出を妨害し,β-カテニンの蓄積につながり,結腸直腸腫瘍形成に寄与します. APCを復元する

さらに関連する動画

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 12, 2014

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium

Published on: May 18, 2021

関連する実験動画

Last Updated: Jun 25, 2026

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 12, 2014

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium

Production of Monoclonal Antibodies Targeting Aminopeptidase N in the Porcine Intestinal Mucosal Epithelium

Published on: May 18, 2021

科学分野:

分子生物学は分子生物学である.
がん研究がん研究
細胞生物学細胞生物学

背景:

Adenomatous polyposis coli (APC) タンパク質の変異は結腸直腸腫瘍に多く見られ,しばしば切断されたタンパク質が生じる.
癌細胞の変異したAPCはβ-カテニンを安定させ,その核転位を促進し,転写共同活性化剤として作用します.
APCは通常,アキシン複合体とプロテアソーム経路経由でβ-カタニンの分解を容易にするが,これは規制作用が十分に理解されていないプロセスである.

研究の目的:

ベータ-カテニンの不安定化におけるAPCの規制的役割を調査する.
APCが核から脱出するメカニズムとそのベータ-カタニンへの影響を特定する.
腫瘍抑制機能のためのAPC核輸出の重要性を決定する.

主な方法:

APCタンパク質における保存された核輸出信号 (NES) の識別と分析.
APC核輸出の正常細胞と APC変異がん細胞の比較.
APC核輸出とβ-カタニンの核蓄積の相関に関する調査.

主要な成果:

高度保存された核輸出シグナルが,APC変異クラスタ領域に隣接する3'で特定されました.
APCの核を脱出する能力は,APC変異がん細胞で失われます.
証拠によると,APC核輸出の喪失は,核にβ-カタニンの蓄積につながると示唆されています.

結論:

保存されたNESによって仲介されたAPCの核輸出は,その機能にとって極めて重要です.
癌細胞におけるAPCの核輸出障害は,β-カタニンの安定化と核蓄積に寄与する.
APCが核から脱出する能力は,結腸直腸がんにおける腫瘍抑制活性に極めて重要です.