歯周病や冠動脈疾患のリスク
P P Hujoel1, M Drangsholt, C Spiekerman
1Department of Dental Public Health Sciences, School of Dentistry, Box 357475, University of Washington, Seattle, WA 98195, USA.
JAMA
|September 16, 2000
まとめ
この研究では,歯周病と冠動脈疾患 (CHD) のリスクを関連付ける説得力のある証拠は見つかりませんでした. 歯茎の健康と心臓病との関連を明らかにするためにさらなる研究が必要である.
科学分野:
- 心血管の健康についてです.
- 口腔衛生は,口腔の健康についてです.
- エピデミオロジー エピデミオロジー
背景:
- 以前の研究で,歯周病と冠動脈性心疾患 (CHD) の関連性が示唆されていた.
- しかし,潜在的な混同要因のために,既存のデータは不確実です.
- この研究は,歯周病とCHDリスクとの関連を明らかにすることを目的とした.
研究 の 目的:
- 歯周病,歯周炎,または歯周病のない人の冠動脈性心疾患 (CHD) のリスクを評価するために.
- 歯周病状態と心血管疾患との関連を調査する.
主な方法:
- 第1回全国保健栄養検査調査 (First National Health and Nutrition Examination Survey) 及び流行病学的フォローアップ研究 (1982-1992) のデータを活用した前向きなコホート研究.
- 以前の心血管疾患のない25歳から74歳までの成人の8032人を含む.
- 歯周病状態 (歯周病,歯周炎,健康) を評価し,心臓病イベント (致死,入院,再血管化) を追跡した.
主要な成果:
- フォローアップ期間中,1265人の個人がCHDイベントを経験しました.
- リスク因子 (HR,1.05;95%CI,0.88-1.26) を調整した結果,歯周炎は心臓病リスクと有意な関連性を示さなかった.
- 歯周病は,心血管疾患の発生リスクの非有意な増加と関連していました (HR, 1.14; 95% CI, 0.96-1.36).
結論:
- この研究では,歯周病と冠動脈疾患のリスクとの間の因果関係を確立するための説得力のある証拠が見つかりませんでした.
- 歯周病と心臓の健康との関係については,さらなる調査が必要である.
- 結果は,混同要因が観察された関連性において重要な役割を果たす可能性があることを示唆しています.
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