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Organization of Genes02:07

Organization of Genes

Overview
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Organization of Genes02:07

Organization of Genes

Overview
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

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Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

ゲノミクスは起こる.

V J DiRita1

  • 1Department of Microbiology and Immunology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Science (New York, N.Y.)
|September 19, 2000
PubMed
まとめ

コレラ菌 (Vibrio cholerae) によって引き起こされる重度の下痢性疾患であるコレラは,何世紀にもわたって人類を苦しめてきました. ゲノムシーケンシングは,この危険な微生物が病気を引き起こす方法についての新しい洞察を明らかにしています.

科学分野:

  • 微生物学 微生物学とは
  • ゲノミクスゲノミクスとは
  • 感染症 感染症は感染症です.

背景:

  • コレラは依然として世界的な健康上の重大な脅威であり,歴史的に広範な疫病を引き起こしてきました.
  • 病原体であるVibrio choleraeは,人間に感染する水生細菌である.
  • その病原性を理解することは,効果的な制御戦略の開発に不可欠です.

研究 の 目的:

  • Vibrio choleraeの病原性に関する理解における最近の進歩を探求する.
  • 新しい洞察を明らかにするゲノムシーケンスの役割を強調する.

主な方法:

  • Vibrio choleraeのゲノムシーケンシングについて.
  • 病原体と宿主の相互作用の分析.

主要な成果:

  • ゲノムデータは,Vibrio choleraeの病気を引き起こすメカニズムに関する新しい見方を提供しています.
  • 微生物の病原性の新たな側面が明らかにされています.

結論:

  • ゲノムに関する洞察は,コレラの理解に革命を起こしています.

さらに関連する動画

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
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Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

関連する実験動画

Last Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

  • Vibrio choleraeのゲノミクスに関する継続的な研究は,疾病管理の取り組みを強化します.