IRS-2経路は,女性の生殖とエネルギーホメオスタシスを統合しています
D J Burks1, J Font de Mora, M Schubert
1Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Nature
|October 3, 2000
まとめ
インスリン受容体基板-2 (IRS-2) は,女性の生殖能力に不可欠です. その欠如は不妊症,肥満,ホルモン不均衡を引き起こし,哺乳類の生殖とエネルギーを調節する保存された経路を強調します.
科学分野:
- 生殖内分泌学 生殖内分泌学
- メタボリックシグナリング
- 哺乳類生理学について
背景:
- 栄養素の利用可能性は,哺乳類からC. elegans.まで,種間の生育力に大きな影響を及ぼします.
- 肥満や多囊性卵巣症候群のような疾患は不妊症と関連しています.
- 生殖の成功には,代謝信号と生殖信号の統合が必要である.
研究 の 目的:
- インスリン受容体基板-2 (IRS-2) の女性の生育能力とエネルギーホメオスタシスにおける役割を調査する.
- IRS-2欠乏が生殖器官や内分泌機能に及ぼす影響を明らかにする.
- IRS-2,食欲の調節,および生殖内分泌学の間のリンクを探求する.
主な方法:
- IRS-2ノックアウトマウスの世代.
- 卵巣の形状と卵泡数の分析.
- 血のホルモンレベル (ルテイン化ホルモン,プロラクチン,性ステロイド,レプチン) を測定する.
- pituitary 腺のサイズと gonadotroph 集団の評価.
- 食事の摂取と体重の評価.
主要な成果:
- IRS-2の削除は,小型の無排卵性卵巣と縮小した卵泡を持つ女性の不妊症を引き起こしました.
- IRS-2が欠けていたマウスは,低レベルのルテイン化ホルモン,プロラクチン,および性ステロイドを示した.
- 下垂体腺は,IRS-2欠乏症のマウスの体内では,小胞腺が少なく,小胞腺が小さかった.
- IRS-2欠乏症の女性では,レプチン濃度が高いにもかかわらず,食物の摂取量と肥満が増加しました.
結論:
- IRS-2は哺乳類の雌性生殖に不可欠である.
- レプチンと神経ペプチドによって調節されるインスリンシグナル伝達は,食欲と生殖の視床下部制御に影響を与えます.
- IRS-2を含む進化的に保存されたメカニズムは,生殖とエネルギーホメオスタシスを両方を調節します.
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