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関連する概念動画

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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関連する実験動画

Updated: Jul 9, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

免疫阻害受容体とは

J V Ravetch1, L L Lanier

  • 1Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10021, USA.

Science (New York, N.Y.)
|October 6, 2000
PubMed
まとめ

免疫反応は,適切な調節のために,活性化信号と抑制信号の両方を必要とします. これらの信号のバランスをとることは,障害が重度の自己免疫疾患につながる可能性があるため,非常に重要です.

科学分野:

  • 免疫学 免疫学とは
  • 細胞生物学 細胞生物学

背景:

  • 免疫反応は,活性化信号と阻害信号のバランスによって厳しく調節されます.
  • 阻害性受容体は,免疫細胞機能を調節する上で重要な役割を果たします.
  • 免疫チェックポイントの調節不良は,自己免疫疾患につながる可能性があります.

研究 の 目的:

  • 免疫細胞の抑制受容体システムを分析する.
  • 免疫反応におけるペアリングされた活性化と抑制のパラダイムを理解する.
  • これらの規制メカニズムの進化的意義を強調する.

主な方法:

  • 抑制性受容体システムの詳細な説明と分析.
  • リンパ性および骨髄性細胞の相互作用の検査.
  • 受容体の信号伝達経路の比較分析.

主要な成果:

  • 中心的なパラダイムが生まれました:ペアリングされた活性化と抑制は,免疫反応を開始し,増幅し,終了します.
  • 類似したリガンドを認識する受容体からの対極信号が,純免疫結果を決定する.
  • ネズミの抑制受容体の標的の破壊は,重度の自己免疫疾患を引き起こした.

さらに関連する動画

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
07:52

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

関連する実験動画

Last Updated: Jul 9, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
07:52

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

結論:

  • 活性化受容体と阻害受容体のバランスは,免疫ホメオスタシスのために不可欠です.
  • 抑制性受容体は,自己免疫を予防する上で重要な役割を果たします.
  • 免疫受容体チロシンベースの抑制モチーフの保存は,それらの根本的な重要性を強調します.