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Updated: Aug 2, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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神経科学. 神経科学. 神経科学. ガンマ分泌酵素の共犯者が注目されるようになった

S S Sisodia1

  • 1Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA. ssisodia@drugs.bsd.uchicago.edu

Science (New York, N.Y.)
|October 21, 2000
PubMed
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No abstract available in PubMed .

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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...