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Updated: May 2, 2026

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
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Published on: September 8, 2010

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Egfr経路のネガティブレギュレータであるD-cblは,ドロソフィラオオゲネシスのドロソセントラルパターニングに必要である

L M Pai1, G Barcelo, T Schüpbach

  • 1Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544, USA.

Cell
|October 29, 2000
PubMed
まとめ

D-cblの変異は,ドロソフィラのオオゲネシス中に表皮成長因子受容体 (EGFR) 経路の過活性化を引き起こす. これは,EGFR信号伝達の二重制御を強調し,適切な細胞運命を決定するために,リガンド活性化とD-cbl抑制の両方を要求します.

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