睡眠不足が24時間の成長ホルモン分泌全体に与える影響

G Brandenberger, C Gronfier, F Chapotot

Lancet (London, England)

|October 29, 2000

まとめ

睡眠不足は,夜間の成長ホルモン (GH) の放出を鈍くしますが,昼間の分泌は補償します. 日々のGHの総分泌量は類似しており,睡眠障害が子供のGH欠乏による成長を阻害しないことを示唆しています.

科学分野:

エンドクリノロジーエンドクリノロジー
スリープ・サイエンススリープ・サイエンス
小児の成長について

背景:

睡眠不足はホルモン調節,特に成長ホルモン (GH) の分泌に影響します.
GH放出の昼間パターンは,主に睡眠開始と関連しています.

研究の目的:

急性睡眠不足が24時間の成長ホルモン (GH) の分泌に与える影響を調査する.
鈍化した夜間GHパルスが昼間の分泌によって補償されているかどうかを判断する.
睡眠障害がGH欠乏によって成長を阻害するという仮説に取り組むために.

主な方法:

コントロールされた睡眠不足プロトコルを使用しました.
24時間監視された成長ホルモン (GH) の分泌パターン.
睡眠不足の個体と対照群のGHレベルを比較した.

主要な成果:

睡眠不足は,睡眠に関連した正常なGHパルスを鈍化させました.
日中のGH分泌は,夜間脈拍の鈍化を大幅に補償した.
24時間の総GH分泌量は,睡眠不足状態と睡眠不足状態でない状態の間で比較可能でした.

結論:

急性睡眠不足は,GHの分泌量の日々の赤字につながらない.
身体は,睡眠に関連したGHの放出が失われたことを補償します.
子どもの睡眠障害は,毎日のGH欠乏によってのみ,成長を抑制する可能性は低い.

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