リンクされた遺伝子のタンパク質は,似たような速さで進化する
1Department of Biology and Biochemistry, University of Bath, Claverton Down, UK.
Nature
|November 1, 2000
まとめ
タンパク質の進化の速度は大きく異なるが,リンクされた遺伝子は同様の進化速度を示している. この類似性は,再結合率の影響を受け,タンパク質の進化における選択の安定化に役割を果たしていることを示唆しています.
科学分野:
- 進化生物学の進化生物学について
- 分子進化は分子進化である.
- 遺伝学 遺伝学とは
背景:
- タンパク質の進化の速度は著しく変動し,根本的な原因はほとんど解明されていない.
- 基本性やアミノ酸組成などの以前の仮説は,これらの進化速度の違いを一貫して説明できませんでした.
- タンパク質の進化に影響を与える既知の要因には,敵対的な共進化と遺伝子変異率が含まれます.
研究 の 目的:
- タンパク質の進化速度の新たな予測要因を特定する.
- リンクされた遺伝子の進化速度の間の関係を調査する.
- タンパク質の進化に対する再結合と選択の影響を調査する.
主な方法:
- 遺伝子間のタンパク質の進化率の統計分析.
- 関連遺伝子の進化速度を評価するための比較ゲノミクス.
- 進化の速度と,突然変異や再結合のようなゲノム系因子との相関分析.
主要な成果:
- タンパク質の進化速度の統計的に有意な新しい予測要因が特定されました.
- リンクされた遺伝子は,タンパク質の進化の相似率を示しています.
- タンパク質の進化率と再結合率の間の負の相関が観察され,安定性の選択を示唆した.
結論:
- 遺伝子結合は,似たようなタンパク質の進化速度における重要な要因である.
- 再結合率と安定性の選択は,タンパク質の進化を調節する役割を果たしているようです.
- この発見は,分子進化の原動力に関する新しい洞察を提示する.
さらに関連する動画
12:05A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
Published on: October 1, 2017
07:35Rapid, Enzymatic Methods for Amplification of Minimal, Linear Templates for Protein Prototyping using Cell-Free Systems
Published on: June 14, 2021
関連する概念動画
03:06From DNA to Protein
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
02:05Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
02:05DNA as a Genetic Template
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
01:20The Central Dogma
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
02:05Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
02:05DNA as a Genetic Template
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...