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グレリンは,ネズミの脂肪を誘発する
M Tschöp1, D L Smiley, M L Heiman
1Endocrine Research and BioResearch Technologies & Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA. Matthias_Tschoep@Lilly.com
Nature
|November 1, 2000
まとめ
胃ホルモンであるグリリンは,脂肪の使用を減らし,食物の摂取量を増加させることで,体重増加を誘発します. このペプチドホルモンは下垂体に信号を送り,エネルギーバランスと成長ホルモンの分泌に影響を与えます.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 神経科学は神経科学である.
- メタボリック・レギュレーション
背景:
- 成長ホルモン分泌剤 (GHS) 受容体の内生リンガンドであるグリリンは,主に胃で合成されます.
- GHS受容体は pituitary, hypothalamus,および脳幹に存在し,さまざまな生理学的役割を示唆しています.
- グレリンの役割は,成長ホルモン (GH) の分泌を超えて,潜在的にエネルギーバランスの調節のために胃と中枢神経系を結びつける.
研究 の 目的:
- エネルギーバランスと体重の調節におけるグレーリンの役割を調査する.
- 周辺および中央グルリンの投与が食事の行動と代謝に与える影響を決定する.
- ネズミの栄養状態に対するグレリンの反応を調べる.
主な方法:
- ネズミとネズミでグレリンの周周回および脳内静脈内投与.
- 体重,食物の摂取,脂肪の利用の測定.
- 断食と再給餌に反応する血清グリリン濃度のモニタリング.
主要な成果:
- 周辺グレリンの投与は,ネズミの脂肪の利用を減少させることにより,体重増加につながった.
- 脳内静脈内グルリンの投与は,摂取量の量に依存して,食物の摂取量と体重を増加させた.
- ネズミの血清グレーリンの濃度は,断食で増加し,再給食やグルコース投与で減少した.
結論:
- グレリンは,エネルギーホメオスタシスと体重の調節に重要な役割を果たします.
- グレリンは中央的に働き,食欲を刺激し,体重増加を促進します.
- グレリンは,胃から下垂体への内分泌信号として機能し,代謝効率の向上の必要性を示す.
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