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Updated: Jun 30, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

TRAF6によるIkappaBキナーゼ複合体の活性化には,二次元的なユビキチン結合酵素複合体とユニークなポリユビキチン鎖が必要である

L Deng1, C Wang, E Spencer

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA.

Cell
|November 1, 2000
PubMed
まとめ

腫瘍死滅因子受容体関連因子6 (TRAF6) は,リシン-63 (K63) ポリユビキチン鎖を介してイカッパBキナーゼ (IKK) を活性化します. この新しいユビキチンシグナル伝達経路は,炎症性サイトカインに対する反応としてNF-kappaBの活性化に不可欠です.

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