電子ビームコンピュータトモグラフィーによる冠動脈微血管機能の最小侵襲的評価
S Möhlenkamp1, L O Lerman, A Lerman
1Department of Physiology, Internal Medicine, Division of Hypertension, Mayo Clinic, Rochester, MN, USA.
Circulation
|November 9, 2000
まとめ
高コレステロール血症は,心筋の血流量と体積の準備,特に徴用可能な微循環を損なう. 電子ビームコンピューティングトモグラフィー (EBCT) は,高コレステロール血症のような状態において,これらのマイクロ血管の変化を評価することができます.
科学分野:
- 心血管の生理学 心血管の生理学
- 医学画像検査 医学画像検査
- マイクロ循環の研究
背景:
- 電子ビームコンピューティングトモグラフィー (EBCT) インジケーター-希釈法では,心内血量 (BV) と輸血量 (F) を推定します.
- 関連BV=aF+b√Fは,募集可能な (a) および募集できない (b) 微循環成分を特徴づけている.
- 高コレステロール血症 (HC) は,マイクロ血管機能を変化させる可能性があります.
研究 の 目的:
- EBCTによるBVとFと,ドップラー超音波による冠動脈血流 (CBF) を比較する.
- 正常およびHCの豚の血管活性薬に対する微血管反応の差異を定量化する.
- 高コレステロール血症が心筋小循環に与える影響を評価する.
主な方法:
- 14匹のHCと14匹の対照ブタを対象としたコントラスト強化EBCT研究.
- ベースラインおよびアデノシンおよびニトログリセリン注入後のBV,F,CBFの測定.
- 微血管の準備量と機能的成分分布の分析.
主要な成果:
- アデノシン誘発のBVとCBFの貯蔵量はHC豚で弱まった (P<0.03とP<0.01).
- HCブタは,対照群と比較して,一貫して採用可能なBVが低いことを示しました.
- また,HCのブタ (P<0.001) の場合も,再利用できないBVの準備が弱まり,抵抗器の機能が損なわれていることが示された.
結論:
- EBCTは,心内微循環機能の最小侵襲的評価を可能にします.
- EBCTは,マイクロ血管の血液の体積分布を,機能的成分に評価することができます.
- この方法は,高コレステロール血症のような病理生理学的状態における冠動脈微循環の評価に有用である.
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