関連する実験動画

Updated: Jul 13, 2026

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

Pit-1 DNAサイトが,細胞型特異化における長期抑制に及ぼすアロステリック効果

K M Scully1, E M Jacobson, K Jepsen

  • 1Howard Hughes Medical Institute, Department of Endocrinology and Metabolism, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Science (New York, N.Y.)
|November 10, 2000
PubMed
まとめ

下垂体因子Pit-1は,体内ホルモンの成長ホルモンを活性化するが,乳内ホルモンの成長ホルモンを抑制する. 遺伝子調節におけるこの二重の役割は,DNAプロモーターの間隔とコアプレッサーの採用によって決定される.

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