精神的なストレスは,ヒトにおける一時的な内皮機能障害を誘発する.
L Ghiadoni1, A E Donald, M Cropley
1Vascular Physiology Unit, Great Ormond Street Hospital for Children NHS Trust, London WC1 3JH, UK.
Circulation
|November 15, 2000
まとめ
精神的なストレスは,健康な個人の内皮機能を一時的に損なっており,ストレスを動脈硬化症と関連付けている可能性がある. この効果は,フローメディエートされた膨張で測定され,4時間以内に解消します.
科学分野:
- 心血管生理学 心血管の生理学
- ストレス生理学 ストレス生理学
- 内皮機能の機能について
背景:
- 精神的ストレスは,心血管疾患の罹患率と死亡率と関連しています.
- 内皮損傷は,ストレスと動脈硬化症の進行を結びつける提案されたメカニズムです.
研究 の 目的:
- 健康な男性および糖尿病患者の内皮機能に対する急性精神的ストレスの影響を調査する.
- 精神的ストレスが内皮に依存した血管拡張と独立した血管拡張に影響を与えるかどうかを評価する.
主な方法:
- 腕動脈の流動媒介拡張 (内皮質依存) とグリセリルトリニトラート反応 (内皮質依存) を超音波で評価した.
- 健康な男性と糖尿病の男性で標準化された精神的ストレステストの前に,そして後に測定された反応.
- 精神的なストレスを感じない健康な男性で,昼間の効果をコントロールするために,繰り返し測定を行った.
主要な成果:
- 健康な男性は,精神的なストレスから30分と90分後にフローメディエイトされた膨張が有意に減少し,4時間後にベースラインに戻った.
- 精神的ストレスは,健康な男性におけるグリセリル三酸塩に対する反応を変化させなかった.
- 糖尿病の男性では,ベースラインより低いフローメディエイトの膨張があり,精神的なストレスの後に有意な変化を示しませんでした.
結論:
- 短期的な精神的ストレスは,健康な個人に一時的な内皮機能不全を引き起こす.
- この一時的な機能障害は,精神的ストレスと動脈硬化症の発達との間のメカニズム的なリンクかもしれません.
- 糖尿病患者は,おそらくすでに機能障害があるため,ストレスによって引き起こされた内皮の変化を示さなかった.
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