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Updated: Jun 30, 2026

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

クローン病に対するインフリキシマブの失敗のメカニズム

S Nikolaus1, A Raedler, T Kühbacker

  • 1Christian-Albrechts-University, First Department of Medicine, Kiel, Germany.

Lancet (London, England)
|November 18, 2000
PubMed
まとめ

インフリキシマブは当初,ほとんどの患者でクローン病の症状を改善したが,腫瘍死滅因子アルファ (TNF-alpha) や核因子カッパB (NFkappaB) などの免疫マーカーが症状が再発する前に再活性化されるため,多くの患者が再発した.

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