女性の認知機能低下は,タンパク質に結合しないエストラジオール濃度と関係しています
1Department of Psychiatry, University of California, San Francisco 94121, USA. kyaffe@itsa.ucsf.edu
Lancet (London, England)
|November 21, 2000
まとめ
高齢の女性において,自由で生物利用可能なエストラディオールのレベルが高くなることは,認知機能低下のリスクの低下と関連していた. これは,内生性エストロゲンが認知機能の維持に保護的役割を果たしていることを示唆しています.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 神経科学は神経科学である.
- ゲロントロジーはゲロントロジーの学科です.
背景:
- 以前の研究では,総エストラジオールと認知機能の関連性は見つかりませんでした.
- 血清ホルモンのレベルは,脳でアクセス可能なホルモン濃度を反映しない可能性があります.
- 高齢女性の認知機能に関連して,自由で生物利用可能な性ホルモンを研究した.
研究 の 目的:
- タンパク質に結合しない (自由) および緩い結合 (生物利用可能) の性ホルモン濃度が,高齢女性における認知機能と関連しているという仮説を検証する.
- 特定のホルモンのレベルが高齢女性における認知機能低下を予測するかどうかを判断する.
主な方法:
- 認知能力は,基値と6年後に修正されたミニメンタルステータス試験 (mMMSE) を使用して評価されました.
- 425人の女性 (≥65歳) でRIAで測定されたタンパク質に結合しないおよび生物利用可能なエストラディオールとテストステロンの血清濃度.
主要な成果:
- エストラディオールまたはテストステロンによる初期認知スコアに違いはありません.
- タンパク質に結合しないエストラジオールの最高三位数の女性では,認知機能障害の確率が著しく低下しました (調整されたOR 0.3).
- 生物利用可能なエストラディオールには同様の保護的関連が観察されましたが,テストステロンには関連性が見つかりませんでした.
結論:
- タンパク質に結合しない生物利用可能なエストラディオールの血清濃度が高いことは,認知障害を発症する確率が低いことと関連しています.
- 研究結果は,内生性エストロゲンのレベルが上昇すると,高齢女性の認知機能低下を防ぐ可能性があるという仮説を裏付けている.
- テストステロンレベルは,認知障害のリスクと関連性がないことが示されました.
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