初期の母親の鉄貯蔵が胎盤の重量と構造に与える影響
P C Hindmarsh1, M P Geary, C H Rodeck
1London Centre for Paediatric Endocrinology, University College London, UK. p.hindmarsh@ucl.ac.uk
Lancet (London, England)
|November 21, 2000
まとめ
母親の鉄分状態,特に低フェリチンのレベルは,胎盤のサイズと出生体重に影響します. 妊娠前の十分な鉄と葉酸の確保は,健康的な妊娠の結果にとって極めて重要です.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 妊産婦・胎児医学について
- 栄養科学とは,栄養科学である.
背景:
- 胎盤の大きさと低出生体重は,成人の高血圧に関連しています.
- 母親の貧血は潜在的に寄与する要因である.
- 母親の鉄分状態と,出生体重や胎盤のサイズに影響を与える他の要因との相互作用を調査した.
研究 の 目的:
- 母親の鉄分状態が社会経済的要因と対等性との相互作用を検証する.
- 低リスク妊娠における胎盤のサイズと出生体重の決定要因を理解する.
- 母親の鉄分状態と胎盤の形態学の関係を探求する.
主な方法:
- 1650人の低リスクシングルトンの白人の妊娠を対象とした展望的研究.
- 胎盤のサイズと出生体重が,母親の鉄分状態,社会経済的な地位,および均等性に関連している.
- ランダムに選択された17例の初胎妊娠で胎盤の形態を評価した.
主要な成果:
- パリティは出生体重と胎盤体重の両方に有意な影響を及ぼしました.
- 予約時の母親の身長,体重,血清フェリチンは胎盤体重に影響を及ぼしたが,ヘモグロビンには影響はなかった.
- 血清フェリチンの濃度は,葉酸の摂取量と均等性と相関し,逆には胎盤の血管化と相関する.
結論:
- 母親の貧血は胎盤のサイズと出生体重の変動と関連しています.
- 妊娠初期にフェリチンのレベルが低いと,胎盤の血管化が増加することが相関する.
- 鉄と葉酸の状態を含む妊娠前の健康状態は,特に高リスクの女性にとって不可欠です.
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