冠動脈疾患の患者のバロレフレクスの感度と心拍の変動に対する在宅運動トレーニングの効果:ランダム化され,コントロールされた研究
F Iellamo1, J M Legramante, M Massaro
1Dipartimento di Medicina Interna, Centro di Riabilitazione Madonna della Letizia, Università di Roma, Tor Vergata, Rome, Italy. iellamo@med.uniroma2.it
Circulation
|November 22, 2000
まとめ
運動トレーニングは,冠動脈疾患の患者におけるバロレフレクスの感度 (BRS) と心拍の変動性を有意に改善しました. この心臓の自律的機能の強化は,心不全性疾患の二次予防戦略の重要な要素として運動をサポートします.
科学分野:
- 心臓病学 心臓病学
- 運動生理学 運動生理学
- 自律神経科学とは
背景:
- 心筋梗塞の後の心筋梗塞 (MI) の心臓事象の予測要因であるバロレフレクスの感度 (BRS) を低下させる.
- 抑うつ状態のBRSは,自律的な心血管の調節が損なわれていることを示します.
研究 の 目的:
- 冠動脈疾患 (CAD) の患者におけるバロレフレクスの感受性 (BRS) に対する運動トレーニングの効果を調査する.
主な方法:
- 前発性心筋梗塞 (MI) の有無または有無の97人の男性患者は,再循環化後の訓練された (TR) または訓練されていない (UTR) グループにランダムに分けられました.
- TRグループは,HRmaxの85%で2週間の集中運動プログラム (一日2回,週6日) を受けました.
- RR-インターバル標準偏差 (RRSD) によるBRSと心拍数変動 (HRV) は,ベースラインと試験終了時に測定されました.
主要な成果:
- 運動トレーニングは,TRグループでBRS (3.0〜5.3 ms/mmHg) とRRSD (18.7〜23.6 ms) を有意に増加させた (P<0.001およびP<0.01).
- UTRグループでは,BRSやRRSDの有意な変化は見られなかった.
- BRSとRRSDの改善は,TRグループ内の前回のMIとそれのない両方の患者で観察されました.
結論:
- 運動トレーニングは,冠動脈疾患の患者でBRSとHRVを効果的に強化します.
- 運動訓練による自律機能の改善は,心不全性疾患の二次予防に寄与する可能性があります.
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