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低出生体重の9歳児における内皮機能の障害と頸動脈の硬さの増加
1Department of Women and Child Health, Division of Neonatology, Karolinska Hospital, Department of Clinical Science, Unit of Obstetrics and Gynecology, Huddinge Hospital, Karolinska Institutet, Stockholm, Sweden. helena.martin@kbh.ki.se
Circulation
|November 30, 2000
まとめ
低出生体重 (LBW) で生まれた子供は,内皮機能の障害と頸動脈の硬さの増加を示します. これらの早期の血管の変化は,成人における心血管疾患のリスクを増やす可能性があります.
科学分野:
- ペディアトリック・カルディオロジー
- 血管生物学 血管生物学
- 公衆衛生は公衆衛生である.
背景:
- 低出生体重 (LBW) は,成人の心血管疾患と関連しています.
- 内皮機能障害と動脈の弾力性の低下は,高血圧と動脈硬化症の初期指標です.
- この研究では,LBWとLBWなしの青春期前の子供におけるこれらの血管マーカーを調査しました.
研究 の 目的:
- LBWの子供の内皮機能を評価する.
- LBWの子供の動脈の弾力性を評価するために.
- LBWが血管不全の早期徴候と関連しているかどうかを判断する.
主な方法:
- アセチルコリンとニトログリセリンを用いた内皮依存および内皮独立の血管拡張を評価し,レーザードップラーで皮膚 perfusion を測定した.
- 超音波血管壁追跡システムを用いて腹部大動脈と常動脈の弾力性を測定しました.
- 22人のLBW児と22人の正常出生体重の対照群の血管マーカーを比較した.
主要な成果:
- LBWの子どもたちは,対照群と比較して,内皮に依存した血管拡張が有意に低下したことを示した (88+/-33 PU vs. 133+/-34 PU,P<0.001).
- グループ間では,大動脈または頸動脈の弾力性に違いは認められなかった.
- 出生体重と頸動脈の硬さとの間の負の相関が認められた (r=-0.45,P<0.01).
結論:
- LBW歴のある学童は,内皮機能の障害を示しています.
- LBWの子どもでは,頸動脈の硬さが増加する傾向が観察されました.
- これらの発見は,LBW個体における早期の血管の妥協を示唆し,将来の心血管疾患の感受性を潜在的に高めます.
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