ノッチシグナリングとソミットセグメンテーションクロックの同期
Y J Jiang1, B L Aerne, L Smithers
1Vertebrate Development Laboratory, Imperial Cancer Research Fund, London, UK.
Nature
|December 2, 2000
まとめ
ノッチ・シグナリングは,脊椎動物のソミトゲネシスに不可欠であり,適切なセグメンテーションのためにプレソミト性メソデーム細胞の同期した振動を保証します. この同期は,体軸のセグメントを形成する鍵です.
科学分野:
- 発達生物学 発達生物学とは
- 細胞シグナリング
背景:
- 脊椎動物におけるソミトセグメンテーションは,胚の発達に極めて重要です.
- Notch細胞-細胞通信経路の突然変異は,ソミトの形成を妨害する.
- ソミトゲネシスにおけるノッチ信号の正確な役割は不明である.
研究 の 目的:
- 脊椎動物胚のセグメンテーションプロセスにおけるノッチ信号の機能を調査する.
- ノッチ信号がソミトゲネシスに影響を与えるメカニズムを解明する.
主な方法:
- Notch経路に欠陥があるゼブラフィッシュ変異体の分析.
- プレソミティック・メソデーム内の細胞振動を調査する.
主要な成果:
- ノッチ・シグナリングは振動そのものに欠かせないが,隣接する細胞間の振動を同期させるのに欠かせない.
- Notchシグナル伝達の障害は,非同期の振動と不規則なソミット境界につながる.
- これは,セグメンテーション中の細胞行動の調整におけるノッチの新たな役割を強調しています.
結論:
- ソミトゲネシスにおけるノッチ信号の主要な役割は,プレソミト性メソダームの同期した振動を維持することです.
- Notchシグナリングによる細胞サイクル同期は,ソミットの正確なパターニングと形成に不可欠です.
関連する概念動画
03:14Notch Signaling Pathway
6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
02:33Hedgehog Signaling Pathway
10.2K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.2K
02:13Determining the Plane of Cell Division
4.0K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
4.0K
02:19The Spindle Assembly Checkpoint
3.9K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.9K