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Updated: Jul 8, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

免疫グロブリン軽鎖遺伝子の体的再結合部位における配列

H Sakano, K Hüppi, G Heinrich

    Nature
    |July 26, 1979
    PubMed
    まとめ

    研究者はマウスの免疫グロブリンカッパ鎖DNAを配列化し,5つの結合 (J) DNAセグメントを特定しました. この研究は,正確な再結合部位を明らかにし,体再結合中のDNAセグメント切除が抗体多様性に寄与することを示唆しています.

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