アラビドプシスの転写因子:ユカリオットの全ゲノム比較分析
J L Riechmann1, J Heard, G Martin
1Mendel Biotechnology, 21375 Cabot Boulevard, Hayward, CA 94545, USA. jriechmann@mendelbio.com
Science (New York, N.Y.)
|December 16, 2000
まとめ
アラビドプシス・タリアナは1500以上の転写因子を持ち,多くの植物特異的な家族を持っています. 比較分析により,エウカリオットのトランスクリプションの規則における進化的差異が明らかになり,系統特異的なDNA結合ドメインの組み合わせが強調されています.
科学分野:
- 比較ゲノミクスとは
- 分子進化は分子進化である.
- 転写因子ファミリー
背景:
- アラビドプシス・サリアナのゲノムの配列決定は,大規模な比較分析の基礎となる.
- 転写因子 (TF) は,遺伝子発現の重要な調節体であり,基本的な生物学的プロセスを制御します.
- TFの進化を理解することは,生命の多様化についての洞察を提供します.
研究 の 目的:
- アラビドプシス・タリアナの転写レギュレータと,他の真核生物王国のレギュレータを比較分析する.
- 転写因子ファミリーの進化的起源と多様化を調査する.
- DNA結合ドメインとその配列の保存と分散を調査する.
主な方法:
- アラビドプシス・タライアナの転写因子の全ゲノム識別と分類.
- アラビドプシスTFファミリーの比較分析,他の真核系系におけるオートロゴと.
- 保存されたDNA結合ドメインとその組み合わせパターンのバイオ情報分析.
主要な成果:
- アラビドプシス・タリアナは1500以上の転写因子をコードし,約45%は植物特異家族に属しています.
- すべての真核生物に共通するTFは,保存されたDNA結合領域の外では限られた類似性を示しています.
- 保存されたDNA結合ドメインの重要な系統特有の配列が観察されました.
結論:
- アラビドプシス・タリアナのゲノムには,多くの植物特異的なものを含む,大量に存在する転写因子のレパートリーがあります.
- 進化の過程は,特に保存ドメインの組み合わせ使用を通じて,転写調節の多様性を生み出しました.
- 比較ゲノミクスは,真核王国における転写因子ファミリーにおける異なった進化の軌道を明らかにしている.
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