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Updated: May 12, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

シルデナフィルによる交感性活性化.

B G Phillips1, M Kato, C A Pesek

  • 1Division of Clinical and Administrative Pharmacy, Department of Internal Medicine, University of Iowa, Iowa City, USA.

Circulation
|January 11, 2000
PubMed
まとめ
この要約は機械生成です。

シルデナフィルは,休息状態やストレス状態で交感神経系の活動を著しく増加させます. この増加した交感性活性化は,シルデナフィルの使用に関連した心血管疾患に関連している可能性があります.

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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

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関連する実験動画

Last Updated: May 12, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

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科学分野:

  • 心血管生理学 心血管の生理学
  • 神経薬理学神経薬理学について

背景:

  • シルデナフィル・シトラートは,勃起不全の治療に用いられる一般的な薬です.
  • 神経循環とストレス反応に対するその影響は十分に理解されていません.

研究 の 目的:

  • シルデナフィルの循環神経制御への影響を調査する.
  • ストレス中の神経循環反応に対するシルデナフィルの影響を評価する.

主な方法:

  • 14人の健康なボランティアは,ダブルブラインド・クロスオーバー研究で,シルデナフィル100mgまたはプラセボを投与された.
  • 測定対象には,血圧,心拍数,前腕の血管抵抗,交感神経の活動,およびプラズマカテキオラミンが含まれていた.
  • 様々な身体的,精神的なストレスに対する反応が評価されました.

主要な成果:

  • シルデナフィルは,プラセボと比較して,筋肉の交感神経活性 (141%) と血のノルエピネフリン濃度 (31%) を著しく増加させた.
  • ストレス中の交感性神経の流れは,シルデナフィルの2~8倍の高さであった.
  • 血圧や心拍数などの血液動力学的指標は,グループごとに類似していた.

結論:

  • シルデナフィルは,有意な交感神経系の活性化を誘発する.
  • この活性化は,休息状態と生理学的ストレス要因の間に発生します.
  • 発見は,シルデナフィルの使用に関連した心血管疾患の潜在的なメカニズムを示唆しています.