アルコール摂取と断続的な閉塞の危険性について,フレイミングハム心臓研究 (Framingham Heart Study) で行われた
L Djoussé1, D Levy, J M Murabito
1Department of Medicine, Section of Preventive Medicine & Epidemiology Boston University School of Medicine, Boston, Massachusetts, USA. ldjousse@bu.edu
Circulation
|January 11, 2000
まとめ
適度なアルコール,特にワインとビールの摂取は,断続性閉塞 (IC) の発生リスクを軽減する可能性があります. 最も低いリスクは,13~24g/dを摂取する男性と7~12g/dを摂取する女性で観察されました.
科学分野:
- 心血管疾患の疫学について
- アルコールに関する研究
- 外周動脈疾患は,外周動脈疾患である.
背景:
- 断続的な閉塞 (IC) は,心血管疾患 (CVD) のリスクの増加と関連しています.
- アルコール摂取とICの発症の関連性は十分に確立されていません.
- 以前の研究では,アルコール摂取とICリスクに関する矛盾した結果が出ています.
研究 の 目的:
- アルコールの摂取量と断続性閉塞の発生率との関係を調査する.
- 異なる種類のアルコール飲料がICリスクにどのように影響するか調べる.
- フレミングハム心臓研究 (Framingham Heart Study) の参加者のデータを分析するために.
主な方法:
- アルコールの消費量を5つのレベル (0, 1-6, 7-12, 13-24, >/=25g/d) に分類した.
- 414人の被験者を平均6.8年にわたってICの発達について追跡した.
- アルコール摂取とICリスクとの関連性を分析するために多変量コックス回帰を用いた.
主要な成果:
- 男性と女性のアルコールの消費カテゴリー全体でIC発生率についてJ型曲線が観察されました.
- 最低のICリスクは,男性では1日13~24g (HR:0.67),女性では1日7~12g (HR:0.44) であった.
- ICに対する保護効果は,主に適度なワインとビールの消費と関連していました.
結論:
- 適度なアルコールの摂取は,中断性クラウジケーションに対する保護効果があるようです.
- 最適な保護レベルは,男性では1日13~24g,女性では7~12gと特定されました.
- ワインとビールの消費は,ICリスクの低下と最も有意な関連性を示しました.
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