適度な体重変化と睡眠による呼吸障害の長期的研究
P E Peppard1, T Young, M Palta
1University of Wisconsin School of Medicine, Department of Preventive Medicine, 502 N Walnut St, Madison, WI 53705, USA. ppeppard@facstaff.wisc.edu
JAMA
|December 21, 2000
まとめ
体重の変化は,睡眠呼吸障害 (SDB) に著しく影響する. 10%の体重増加はSDBの重症度を高め,体重減少はSDBの重症度を低下させ,体重管理がSDBのコントロールの鍵であることを示唆しています.
科学分野:
- スリープ・メディシン (睡眠医学)
- 肥満に関する研究
- 公衆衛生は公衆衛生である.
背景:
- 過剰な体重は,睡眠呼吸障害 (SDB) と強く関連しています.
- SDBは,米国の人口の中で広範囲にわたる状態です.
- 体重変化とSDBの重症度に関する長期的研究は限られている.
研究 の 目的:
- 体重変化とSDBの重症度との間の独立した縦断的関連性を決定する.
- 体重変動が,アプレア・ヒポプレア指数 (AHI) に与える影響を定量化するために.
主な方法:
- 1989年から2000年まで,人口を対象とした前向きなコホート研究が行われました.
- ウィスコンシン州に住む690人の雇用者は,4年ごとに2回評価されました.
- アプネア・ヒポネア指数 (AHI) の変化と中等から重度のSDBの確率は,体重変化に相対的に評価されました.
主要な成果:
- 10%の体重増加はAHIの32%増加を予測し,10%の体重減少はAHIの26%減少を予測した.
- 体重が10%増加すると,中等から重度のSDBを発症する確率は6倍に増加する.
- これらの関連性は,ベースラインの体重状態とは無関係でした.
結論:
- 体重管理を促進する臨床および公衆衛生のイニシアチブは,既存のSDBを効果的に管理することができます.
- 控えめな体重管理戦略は,新しいSDB症例の発生率を減らす可能性が高い.
- 体重管理は,SDBの総合的なケアにおける重要な要素です.
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