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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Toll型受容体は,細菌のDNAを認識する

H Hemmi1, O Takeuchi, T Kawai

  • 1Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita.

Nature
|December 29, 2000
PubMed
まとめ

CpGモチーフを含む細菌DNAは,免疫細胞を活性化する. 研究者らは,トール型受容体9 (TLR9) がこの反応を媒介することを発見し,自己DNAと外来DNAの区別におけるその役割を強調した.

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